TRPM4 antibody [10H5]

Cannot supply to this region.

SKU:: GTX83489
Additional Names:: transient receptor potential cation channel subfamily M member 4 , LTrpC4 , PFHB1B , TRPM4B , hTRPM4
Application:: WB, IHC-P
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Canine, Human
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Full length human recombinant protein of human TRPM4 (NP_060106) produced in HEK293T cell.
Clone:: 10H5
Uniprot:: Q8TD43
Synonyms:: calcium-activated non-selective cation channel 1;EKVP6;hTRPM4;long transient receptor potential channel 4;LTrpC4;melastatin-4;PFHB1B;transient receptor potential cation channel subfamily M member 4;TRPM4B
Extra Details:: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.

Shipping Conditions:: Blue Ice