USP5 antibody [2F5]

Cannot supply to this region.

SKU:: GTX83431
Additional Names:: ubiquitin specific peptidase 5 , ISOT
Application:: WB, IHC-P, IF, ICC
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Canine, Human, Mouse, Rat
Buffer:: PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
Immunogen:: Full length human recombinant protein of human USP5(NP_003472) produced in HEK293T cell.
Clone:: 2F5
Uniprot:: P45974
Synonyms:: deubiquitinating enzyme 5;isopeptidase T;ISOT;testicular tissue protein Li 218;ubiquitin carboxyl-terminal hydrolase 5;ubiquitin isopeptidase T;ubiquitin specific protease 5 (isopeptidase T);ubiquitin thioesterase 5;ubiquitin thiolesterase 5;ubiquitin-specific protease-5 (ubiquitin isopeptidase T);ubiquitin-specific-processing protease 5
Extra Details:: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of TP53/p53 and an increase in TP53/p53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated TP53/p53 but not with MDM2 for proteasomal recognition.

Shipping Conditions:: Blue Ice