Chk1 antibody [2G1D5]

Cannot supply to this region.

SKU:: GTX83385
Additional Names:: checkpoint kinase 1 , CHK1
Application:: ELISA, WB, IF, ICC
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Unpurified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human, Mouse
Buffer:: Ascites, 0.03% Sodium azide.
Immunogen:: Purified recombinant fragment of CHK1 expressed in E. Coli.
Clone:: 2G1D5
Uniprot:: O14757
Synonyms:: cell cycle checkpoint kinase;Checkpoint kinase-1;Checkpoint, S. pombe, homolog of, 1;CHK1;CHK1 checkpoint homolog;Chk1-S;serine/threonine-protein kinase Chk1
Extra Details:: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]