PTEN antibody [1B8]

Cannot supply to this region.

SKU:: GTX83304
Additional Names:: phosphatase and tensin homolog , 10q23del , BZS , CWS1 , DEC , GLM2 , MHAM , MMAC1 , PTEN1 , PTENbeta , TEP1
Application:: ELISA, Flow Cytometry, WB, IHC-P, IF, ICC
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Unpurified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human, Mouse
Buffer:: Ascites, 0.03% Sodium azide.
Immunogen:: Purified recombinant fragment of PTEN expressed in E. Coli.
Clone:: 1B8
Uniprot:: P60484
Synonyms:: 10q23del;BZS;CWS1;DEC;GLM2;MHAM;mitochondrial phosphatase and tensin protein alpha;mitochondrial PTENalpha;MMAC1;MMAC1 phosphatase and tensin homolog deleted on chromosome 10;mutated in multiple advanced cancers 1;Phosphatase and tensin homolog;phosphatase and tensin-like protein;phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;protein tyrosine phosphatase;PTEN variant PTEN-K267Rfs*9;PTEN variant PTEN-L247*;PTEN variant PTEN-R234Afs*11;PTEN1;PTENbeta;PTENepsilon;TEP1
Extra Details:: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]

Shipping Conditions:: Blue Ice