nNOS antibody

Cannot supply to this region.

SKU:: GTX82905
Additional Names:: nitric oxide synthase 1, neuronal , 2310005C01Rik , N-NOS , NC-NOS , NO , NOS , NOS-I , Nos-1 , bNOS , nNOS
Application:: WB, IHC-P, IHC-Fr, IF, ICC, IP
Physical State:: Liquid
Species Reactivity:: Rat
Purification:: Unpurified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Bovine, Fish, Human, Mouse, Rabbit, Rat, Guinea Pig
Buffer:: Serum diluted with PBS, 0.05% Sodium azide.
Immunogen:: Synthetic peptide corresponding to residues T(724) K R R A I G F K K L A E A V K(739) C of rat bNOS.
Uniprot:: Q9Z0J4
Synonyms:: 2310005C01Rik;b;bNOS;constitutive NOS;N-NOS;NC-NOS;neuronal nitric oxide synthase;neuronal NOS;nitric oxide synthase, brain;nNOS;NO;NOS;NOS type I;Nos-1;NOS-I;peptidyl-cysteine S-nitrosylase NOS1
Extra Details:: Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) & endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. All NOS isoforms contain calmodulin, nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), and flavin mononucleotide (FMN) binding domains. eNOS and bNOS share ~50% sequence homology, and their activity depends on binding to the calcium/calmodulin complex. Both constitutive isoforms respond immediately to increased levels of calcium to produce low levels of NO over a short period of time. bNOS has been found in neurons, peripheral nerve cells, macula densa & pancreatic islet cells.

Shipping Conditions:: Blue Ice