TAB2 antibody [3B5]

Cannot supply to this region.

SKU:: GTX82751
Additional Names:: TGF-beta activated kinase 1 (MAP3K7) binding protein 2 , CHTD2 , MAP3K7IP2 , TAB-2
Application:: ELISA, Flow Cytometry, WB
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Unpurified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: Ascites, 0.03% Sodium azide.
Immunogen:: Purified recombinant fragment of human TAB2 expressed in E. Coli.
Clone:: 3B5
Uniprot:: Q9NYJ8
Synonyms:: CHTD2;MAP3K7IP2;mitogen-activated protein kinase kinase kinase 7-interacting protein 2;TAB-2;TAK1-binding protein 2;TGF-beta-activated kinase 1 and MAP3K7-binding protein 2;TGF-beta-activated kinase 1-binding protein 2
Extra Details:: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. [provided by RefSeq, Jul 2008]