DIO1 antibody, N-term

Cannot supply to this region.

SKU:: GTX81625
Additional Names:: iodothyronine deiodinase 1 , 5DI , TXDI1
Application:: WB
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Affinity Purified; Protein A Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: PBS, 0.09% Sodium azide.
Immunogen:: KLH conjugated synthetic peptide between 30-57 amino acids from the N-terminal region of human DIO1.
Uniprot:: P49895
Synonyms:: 5DI;deiodinase, iodothyronine type I;DIOI;iodothyronine deiodinase type 1;selenoprotein DIO1;thyroxine 5'-deiodinase;thyroxine deiodinase type I (selenoprotein);TXDI1;type 1 DI;type I iodothyronine deiodinase;type-I 5'-deiodinase
Extra Details:: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2018]

Shipping Conditions:: Blue Ice