GTX81061
SREBP1 antibody, Internal
Cannot supply to this region.
- SKU:
- GTX81061
- Additional Names:
- sterol regulatory element binding transcription factor 1 , SREBP1 , bHLHd1
- Application:
- Flow Cytometry, WB, IHC-P
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified; Protein A Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 0.09% Sodium azide.
- Immunogen:
- KLH conjugated synthetic peptide between 349-378 amino acids from the Central region of human SREBF1.
- Uniprot:
- P36956
- Synonyms:
- bHLHd1;class D basic helix-loop-helix protein 1;HMD;IFAP2;SREBP1;sterol regulatory element-binding protein 1;Sterol regulatory element-binding transcription factor 1
- Extra Details:
- This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]
- Shipping Conditions:
- Blue Ice