Acetyl Lysine antibody [1C6]

Cannot supply to this region.

SKU:: GTX80693
Application:: ChIP, Flow Cytometry, WB, IF, ICC, IP, Dot blot
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Mouse
Purification:: Protein G Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Buffer:: PBS, 0.1% BSA, 0.05% Sodium azide.
Immunogen:: Synthetic peptide sequence surrounding the acetylated lysine 9 of histone H3.
Clone:: 1C6
Extra Details:: In the nucleus, DNA is tightly packed into nucleosomes generating an environment which is highly repressive towards DNA processes such as transcription. Acetylation of lysine residues within proteins has emerged as an important mechanism used by cells to overcome this repression. The acetylation of non-histone proteins such as transcription factors, as well as histones appears to be involved in this process. Acetylation may result in structural transitions as well as specific signaling within discrete chromatin domains. The role of acetylation in intracellular signaling has been inferred from the binding of acetylated peptides by the conserved bromodomain. Furthermore, recent findings suggest that bromodomain/acetylated-lysine recognition can serve as a regulatory mechanism in protein-protein interactions in numerous cellular processes such as chromatin remodeling and transcriptional activation.

Shipping Conditions:: Blue Ice