VRK1 antibody [1F6]

Cannot supply to this region.

SKU:: GTX79470
Additional Names:: VRK serine/threonine kinase 1 , PCH1 , PCH1A
Application:: IHC, WB, IHC-P, IF, ICC
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Protein A Purified
Storage Conditions:: 2-8[o]C
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human, Mouse
Buffer:: PBS, 0.1% BSA, 0.05% Sodium azide.
Immunogen:: Recombinant fusion protein GST-VRK1.
Clone:: 1F6
Uniprot:: Q99986
Synonyms:: PCH1;PCH1A;serine/threonine-protein kinase VRK1;vaccinia related kinase 1;vaccinia virus B1R-related kinase 1;Vaccinia-related kinase 1
Extra Details:: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]