GTX79146
ALK (phospho Tyr1586) antibody
Cannot supply to this region.
- SKU:
- GTX79146
- Additional Names:
- ALK,CD246,NBLST3,anaplastic lymphoma receptor tyrosine kinase,ALK receptor tyrosine kinase
- Application:
- IHC-P
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Sequential Chromatography; Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 150mM NaCl, 0.5% BSA, 50% glycerol (Please contact us for BSA-free format), 0.02% Sodium azide.
- Immunogen:
- The antiserum was produced against synthesized phosphopeptide derived from human ALK around the phosphorylation site of tyrosine 1586 (Y-G-Yp-Q-Q).
- Uniprot:
- Q9UM73
- Synonyms:
- ALK tyrosine kinase receptor;Anaplastic lymphoma kinase;anaplastic lymphoma receptor tyrosine kinase;CD246;CD246 antigen;mutant anaplastic lymphoma kinase;NBLST3
- Extra Details:
- This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
- Shipping Conditions:
- Blue Ice