SHP2 (phospho Tyr580) antibody

Cannot supply to this region.

SKU:: GTX78945
Additional Names:: BPTP3,CFC,JMML,METCDS,NS1,PTP1D,PTP2C,PTPN11,SHP2,SHPTP2,SHPTP3,protein tyrosine phosphatase, nonreceptor type 11,protein tyrosine phosphatase non-receptor type 11
Application:: IHC-P
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Sequential Chromatography; Affinity Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human
Buffer:: PBS, 150mM NaCl, 0.5% BSA, 50% glycerol (Please contact us for BSA-free format), 0.02% Sodium azide.
Immunogen:: The antiserum was produced against synthesized phosphopeptide derived from human SHP-2 around the phosphorylation site of tyrosine 580 (R-V-Yp-E-N).
Uniprot:: Q06124
Synonyms:: BPTP3;CFC;JMML;METCDS;NS1;protein-tyrosine phosphatase 1D;protein-tyrosine phosphatase 2C;PTP-1D;PTP2C;SH-PTP2;SH-PTP3;SH2 domain-containing protein tyrosine phosphatase 2;SHP2;tyrosine-protein phosphatase non-receptor type 11
Extra Details:: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]

Shipping Conditions:: Blue Ice