GTX78921
ZAP70 (phospho Tyr493) antibody
Cannot supply to this region.
- SKU:
- GTX78921
- Additional Names:
- ADMIO2,IMD48,SRK,STCD,STD,TZK,ZAP70,zeta chain of T cell receptor associated protein kinase 70
- Application:
- IHC-P
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Sequential Chromatography; Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 150mM NaCl, 0.5% BSA, 50% glycerol (Please contact us for BSA-free format), 0.02% Sodium azide.
- Immunogen:
- The antiserum was produced against synthesized phosphopeptide derived from human Zap-70 around the phosphorylation site of tyrosine 493 (S-Y-Yp-T-A).
- Uniprot:
- P43403
- Synonyms:
- 70 kDa zeta-associated protein;70 kDa zeta-chain associated protein;ADMIO2;IMD48;SRK;STCD;STD;syk-related tyrosine kinase;tyrosine-protein kinase ZAP-70;TZK;ZAP-70;zeta chain of T cell receptor associated protein kinase 70kDa;zeta-chain (TCR) associated protein kinase 70kDa;zeta-chain associated protein kinase, 70kD
- Extra Details:
- This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Shipping Conditions:
- Blue Ice