GluR2 antibody, N-term

Cannot supply to this region.

SKU:: GTX77708
Additional Names:: glutamate ionotropic receptor AMPA type subunit 2 , GLUR2 , GLURB , GluA2 , GluR-K2 , HBGR2
Application:: IHC-Fr
Concentration:: 0.5-1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human, Mouse
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Mouse
Buffer:: PBS, 2% Sucrose, 0.09% Sodium azide.
Immunogen:: A synthetic peptide corresponding to a N-terminal region of Human GluR2.
Uniprot:: P42262
Synonyms:: AMPA-selective glutamate receptor 2;GluA2;gluR-2;gluR-B;GluR-K2;GLUR2;GLURB;glutamate receptor 2;Glutamate receptor ionotropic, AMPA 2;glutamate receptor, ionotropic, AMPA 2;HBGR2;NEDLIB
Extra Details:: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]

Shipping Conditions:: Blue Ice