GTX68036-PRO
Human Securin protein, His tag
Cannot supply to this region.
- SKU:
- GTX68036-PRO
- Additional Names:
- pituitary tumor-transforming 1 , EAP1 , HPTTG , PTTG , TUTR1
- Concentration:
- 0.5 mg/ml
- Physical State:
- Liquid
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Buffer:
- 20mM Tris-HCl, 100mM NaCl, 20% Glycerol, 1mM EDTA, 0.1mM PMSF, no preservatives.
- Immunogen:
- pituitary tumor-transforming 1
- Species:
- Human
- Uniprot:
- O95997
- Synonyms:
- EAP1;Esp1-associated protein;ESP1-associated protein 1;HPTTG;pituitary tumor-transforming 1;pituitary tumor-transforming gene 1 protein;PTTG;securin;tumor-transforming protein 1;TUTR1
- Extra Details:
- The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
- Shipping Conditions:
- Dry Ice