GTX67901-PRO
Human TPMT protein
Cannot supply to this region.
- SKU:
- GTX67901-PRO
- Additional Names:
- thiopurine S-methyltransferase , TPMTD
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Buffer:
- 20mM Tris, 2mM EDTA, 0.2mM PMSF, no preservatives.
- Immunogen:
- thiopurine S-methyltransferase
- Species:
- Human
- Uniprot:
- Q9BS45
- Synonyms:
- S-adenosyl-L-methionine:thiopurine S-methyltransferase;thiopurine S-methyltransferase;TPMTD
- Extra Details:
- This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
- Shipping Conditions:
- Dry Ice