GTX67876-PRO
Human Elongin B protein
Cannot supply to this region.
- SKU:
- GTX67876-PRO
- Additional Names:
- elongin B , SIII , TCEB2
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Buffer:
- 20mM Tris-HCl, 20% Glycerol, 1mM DTT, 0.1mM PMSF, no preservatives.
- Immunogen:
- elongin B
- Species:
- Human
- Uniprot:
- Q15370
- Synonyms:
- elongin 18 kDa subunit;elongin-B;elongin, 18-kD subunit;epididymis secretory sperm binding protein;RNA polymerase II transcription factor SIII p18 subunit;RNA polymerase II transcription factor SIII subunit B;SIII;SIII p18;TCEB2;transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B);transcription elongation factor B polypeptide 2;transcription elongation factor B subunit 2
- Extra Details:
- This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]
- Shipping Conditions:
- Dry Ice