Human SHC1 protein, His tag

Cannot supply to this region.

SKU:: GTX67818-PRO
Additional Names:: SHC adaptor protein 1 , SHC , SHCA
Concentration:: 1 mg/ml
Physical State:: Liquid
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Buffer:: 20mM Tris-HCl, 200mM NaCl, 2mM DTT, 20% Glycerol, 0.1mM PMSF, no preservatives.
Immunogen:: SHC adaptor protein 1
Species:: Human
Uniprot:: P29353
Synonyms:: SH2 domain protein C1;SHC;SHC (Src homology 2 domain containing) transforming protein 1;SHC-transforming protein 1;SHC-transforming protein 3;SHC-transforming protein A;SHCA;Src homology 2 domain-containing-transforming protein C1
Extra Details:: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]