Human HARS protein, His tag

Cannot supply to this region.

SKU:: GTX67451-PRO
Additional Names:: histidyl-tRNA synthetase , CMT2W , HRS , USH3B
Concentration:: 1 mg/ml
Physical State:: Liquid
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Buffer:: 20mM Tris-HCl, 100mM NaCl, 10% Glycerol, 1mM DTT, no preservatives.
Immunogen:: histidyl-tRNA synthetase
Species:: Human
Uniprot:: P12081
Synonyms:: CMT2W;HARS;HisRS;histidine translase;histidine--tRNA ligase, cytoplasmic;Histidyl-tRNA synthetase;HRS;Jo-1 antigen;USH3B
Extra Details:: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]