GTX67135-PRO
Human PPM1A protein, His tag (active)
Cannot supply to this region.
- SKU:
- GTX67135-PRO
- Additional Names:
- protein phosphatase, Mg2+/Mn2+ dependent 1A , PP2C-ALPHA , PP2CA , PP2Calpha
- Application:
- FuncS
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Buffer:
- 10mM Tris-HCl, 50mM NaCl, 1mM MnCl₂, 20% Glycerol, 2mM DTT, no preservatives.
- Immunogen:
- protein phosphatase, Mg2+/Mn2+ dependent 1A
- Species:
- Human
- Uniprot:
- P35813
- Synonyms:
- PP2C-ALPHA;PP2CA;PP2Calpha;protein phosphatase 1A;Protein phosphatase 2C isoform alpha;Protein phosphatase IA
- Extra Details:
- The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
- Shipping Conditions:
- Dry Ice