Human DUSP3 protein, His tag (active)

Cannot supply to this region.

SKU:: GTX66975-PRO
Additional Names:: dual specificity phosphatase 3 , VHR
Application:: FuncS
Concentration:: 1 mg/ml
Physical State:: Liquid
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Buffer:: 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, 2mM DTT, no preservatives.
Immunogen:: dual specificity phosphatase 3
Species:: Human
Uniprot:: P51452
Synonyms:: dual specificity protein phosphatase 3;dual specificity protein phosphatase VHR;serine/threonine specific protein phosphatase;vaccinia H1-related phosphatase;vaccinia virus phosphatase VH1-related;VHR
Extra Details:: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]

Shipping Conditions:: Dry Ice