GTX66924-PRO
Mouse Alkaline Phosphatase (Tissue Non-Specific) protein, His tag (active)
Cannot supply to this region.
- SKU:
- GTX66924-PRO
- Additional Names:
- alkaline phosphatase, liver/bone/kidney , ALP , APTNAP , Akp-2 , Akp2 , TNAP , TNSALP
- Application:
- FuncS
- Concentration:
- 0.5 mg/ml
- Physical State:
- Liquid
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Buffer:
- PBS, 10% Glycerol, no preservatives.
- Immunogen:
- alkaline phosphatase, liver/bone/kidney
- Species:
- Mouse
- Uniprot:
- P09242
- Synonyms:
- Ak;Akp;Akp-2;Akp2;Alkaline phosphatase 2;alkaline phosphatase 2, liver;Alkaline phosphatase liver/bone/kidney isozyme;alkaline phosphatase, tissue-nonspecific isozyme;ALP;APTNAP;T;TNAP;TNSALP
- Extra Details:
- This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is a membrane-bound glycosylated enzyme that catalyzes the hydrolysis of phosphate esters at alkaline pH. The mature peptide maintains the ratio of inorganic phosphate to inorganic pyrophosphate required for bone mineralization. Mice that lack this enzyme show symptoms of osteomalacia, softening of the bones. In humans, mutations in this gene are associated with hypophosphatasia, an inherited metabolic bone disease in which deficiency of this enzyme inhibits bone mineralization leading to skeletal defects. Mutations in the mouse gene mirror the symptoms of human hypophosphatasia. A pseudogene of this gene is present on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
- Shipping Conditions:
- Dry Ice