Human ALDH2 protein (active)

Cannot supply to this region.

SKU:: GTX66919-PRO
Additional Names:: aldehyde dehydrogenase 2 family member , ALDH-E2 , ALDHI , ALDM
Application:: FuncS
Concentration:: 1 mg/ml
Physical State:: Liquid
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Buffer:: 20mM Tris-HCl, 10% Glycerol, 1mM DTT, 1mM EDTA, no preservatives.
Immunogen:: aldehyde dehydrogenase 2 family member
Species:: Human
Uniprot:: P05091
Synonyms:: acetaldehyde dehydrogenase 2;aldehyde dehydrogenase 2 family (mitochondrial);aldehyde dehydrogenase, mitochondrial;ALDH class 2;ALDH-E2;ALDHI;ALDM;epididymis secretory sperm binding protein;liver mitochondrial ALDH;nucleus-encoded mitochondrial aldehyde dehydrogenase 2
Extra Details:: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016]

Shipping Conditions:: Dry Ice