GTX66369
SMG7 antibody
Cannot supply to this region.
- SKU:
- GTX66369
- Additional Names:
- SMG7 nonsense mediated mRNA decay factor , C1orf16 , EST1C , SGA56M
- Application:
- WB
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- PBS, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Recombinant funsion protein containing a sequence corresponding to amino acids 1-300 of human SMG7 (NP_963863.2).
- Uniprot:
- Q92540
- Synonyms:
- breast cancer-associated antigen SGA-56M;C1orf16;EST1 telomerase component homolog C;EST1-like protein C;EST1C;ever shorter telomeres 1C;protein SMG7;SGA56M;SMG-7 homolog;smg-7 homolog, nonsense mediated mRNA decay factor
- Extra Details:
- This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
- Shipping Conditions:
- Blue Ice