GTX66072
Gremlin 1 antibody
Cannot supply to this region.
- SKU:
- GTX66072
- Additional Names:
- gremlin 1, DAN family BMP antagonist , C15DUPq , CKTSF1B1 , CRAC1 , CRCS4 , DAND2 , DRM , DUP15q , GREMLIN , HMPS , HMPS1 , IHG-2 , MPSH , PIG2
- Application:
- WB
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Recombinant funsion protein containing a sequence corresponding to amino acids 44-143 of human GREM1 (NP_001178252.1).
- Uniprot:
- O60565
- Synonyms:
- C15DUPq;cell proliferation-inducing gene 2 protein;CKTSF1B1;colorectal adenoma and carcinoma 1;CRAC1;CRCS4;cysteine knot superfamily 1, BMP antagonist 1;DAN domain family member 2;DAND2;down-regulated in Mos-transformed cells protein;DRM;DUP15q;GREMLIN;gremlin 1-like protein;gremlin 1, cysteine knot superfamily, homolog;gremlin-1;hereditary mixed polyposis syndrome;HMPS;HMPS1;IHG-2;Increased in high glucose protein 2;increased in high glucose-2;MPSH;PIG2
- Extra Details:
- This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
- Shipping Conditions:
- Blue Ice