GTX65902
ALOXE3 antibody
Cannot supply to this region.
- SKU:
- GTX65902
- Additional Names:
- arachidonate lipoxygenase 3 , ARCI3 , E-LOX , eLOX-3 , eLOX3
- Application:
- WB
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Recombinant funsion protein containing a sequence corresponding to amino acids 1-280 of human ALOXE3 (NP_067641.2).
- Uniprot:
- Q9BYJ1
- Synonyms:
- ARCI3;E-LOX;e-LOX-3;eLOX-3;eLOX3;epidermal lipoxygenase;Epidermal lipoxygenase-3;epidermal LOX-3;epidermis-type lipoxygenase 3;hydroperoxide isomerase ALOXE3;hydroperoxy dehydratase ALOXE3;hydroperoxy icosatetraenoate dehydratase;hydroperoxy icosatetraenoate isomerase
- Extra Details:
- This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
- Shipping Conditions:
- Blue Ice