GTX64867
Langerin antibody
Cannot supply to this region.
- SKU:
- GTX64867
- Additional Names:
- CD207 molecule , CLEC4K
- Application:
- WB
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Recombinant fusion protein containing a sequence corresponding to amino acids 69-328 of human CD207 (NP_056532.4).
- Uniprot:
- Q9UJ71
- Synonyms:
- C-type lectin domain family 4 member K;C-type lectin domain family 4, member K;CD207 antigen, langerin;CD207 molecule, langerin;CLEC4K;Langerhans cell specific c-type lectin;Langerin
- Extra Details:
- The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]
- Shipping Conditions:
- Blue Ice