GTX64656
FGD4 antibody
Cannot supply to this region.
- SKU:
- GTX64656
- Additional Names:
- FYVE, RhoGEF and PH domain containing 4 , CMT4H , FRABP , ZFYVE6
- Application:
- WB
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Rat
- Buffer:
- PBS, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Recombinant protein of human FGD4
- Uniprot:
- Q96M96
- Synonyms:
- Actin filament-binding protein frabin;actin-filament binding protein frabin;CMT4H;FGD1 family, member 4;FGD1-related F-actin-binding protein;FRABP;FYVE, RhoGEF and PH domain-containing protein 4;ZFYVE6;zinc finger FYVE domain-containing protein 6
- Extra Details:
- This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
- Shipping Conditions:
- Blue Ice