GTX645429
PCBP2 antibody [HL5177]
Cannot supply to this region.
- SKU:
- GTX645429
- Additional Names:
- poly(rC) binding protein 2 , HNRNPE2 , HNRPE2 , hnRNP-E2
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Protein A Purified
- Storage Conditions:
- 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Buffer:
- PBS, no preservatives.
- Immunogen:
- Recombinant fragment of human PCBP2.
- Clone:
- HL5177
- Uniprot:
- Q15366
- Synonyms:
- alpha-CP2;epididymis secretory sperm binding protein;heterogeneous nuclear ribonucleoprotein E2;heterogenous nuclear ribonucleoprotein E2;hnRNP E2;hnRNP-E2;HNRNPE2;HNRPE2;poly(rC)-binding protein 2
- Extra Details:
- The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]
- Shipping Conditions:
- Blue Ice