GTX644039
JMJD3 antibody [HL4474]
Cannot supply to this region.
- SKU:
- GTX644039
- Additional Names:
- lysine demethylase 6B , JMJD3
- Application:
- WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, no preservatives.
- Immunogen:
- Synthetic peptide of human JMJD3.
- Clone:
- HL4474
- Uniprot:
- O15054
- Synonyms:
- [histone H3]-trimethyl-L-lysine(27) demethylase 6B;jmjC domain-containing protein 3;JMJD3;jumonji domain containing 3, histone lysine demethylase;jumonji domain-containing protein 3;lysine (K)-specific demethylase 6B;Lysine demethylase 6B;lysine-specific demethylase 6B;NEDCFSA
- Extra Details:
- The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]
- Shipping Conditions:
- Blue Ice