![PFKFB4 antibody [HL3254]](https://www.genetex.com/upload/website/prouct_img/normal/GTX640901/GTX640901_T-45523_20240920_WB_R_24092600_399.webp)
![PFKFB4 antibody [HL3254]](https://www.genetex.com/upload/website/prouct_img/normal/GTX640901/GTX640901_T-45523_20240920_WB_TPM_watermark_24092600_654.webp)
GTX640901
PFKFB4 antibody [HL3254]
Cannot supply to this region.
- SKU:
- GTX640901
- Additional Names:
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
- Application:
- WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Rat
- Buffer:
- PBS, no preservatives.
- Immunogen:
- Recombinant fragment of human PFKFB4.
- Clone:
- HL3254
- Uniprot:
- Q16877
- Synonyms:
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4;6PF-2-K/Fru-2,6-P2ase 4;6PF-2-K/Fru-2,6-P2ase testis-type isozyme;bifunctional enzyme with kinase and biphosphatase activities;PFK/FBPase 4
- Extra Details:
- The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
- Shipping Conditions:
- Blue Ice