SYNGAP1 antibody [HL2292]

Cannot supply to this region.

SKU:: GTX638347
Additional Names:: synaptic Ras GTPase activating protein 1 , MRD5 , RASA1 , RASA5 , SYNGAP
Application:: WB, IF, ICC
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human, Mouse
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Mouse, Rat
Buffer:: PBS, no preservatives.
Immunogen:: Recombinant fragmemt of human SYNGAP1
Clone:: HL2292
Uniprot:: Q96PV0
Synonyms:: MRD5;neuronal RasGAP;Ras GTPase-activating protein SynGAP;ras/Rap GTPase-activating protein SynGAP;RASA1;RASA5;synaptic Ras GTPase activating protein 1 homolog;synaptic Ras GTPase activating protein, 135kDa;Synaptic Ras GTPase-activating protein 1;SYNGAP
Extra Details:: This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Shipping Conditions:: Blue Ice