UHRF1 antibody [HL2287]

Cannot supply to this region.

SKU:: GTX638342
Additional Names:: ubiquitin like with PHD and ring finger domains 1 , ICBP90 , Np95 , RNF106 , TDRD22 , hNP95 , hUHRF1 , huNp95
Application:: WB, IHC-P
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: PBS, no preservatives.
Immunogen:: Recombinant fragment of human UHRF1.
Clone:: HL2287
Uniprot:: Q96T88
Synonyms:: E3 ubiquitin-protein ligase UHRF1;hNP95;hUHRF1;huNp95;ICBP90;inverted CCAAT box-binding protein of 90 kDa;Np95;nuclear phosphoprotein 95;nuclear protein 95;nuclear zinc finger protein Np95;RING finger protein 106;RING-type E3 ubiquitin transferase UHRF1;RNF106;TDRD22;transcription factor ICBP90;ubiquitin-like PHD and RING finger domain-containing protein 1;Ubiquitin-like-containing PHD and RING finger domains protein 1
Extra Details:: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]

Shipping Conditions:: Blue Ice