MAP3K8 antibody [HL2118]

Cannot supply to this region.

SKU:: GTX638090
Additional Names:: mitogen-activated protein kinase kinase kinase 8 , AURA2 , COT , EST , ESTF , MEKK8 , TPL2 , Tpl-2 , c-COT
Application:: WB, IHC-P
Concentration:: 2 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Mouse
Buffer:: PBS, no preservatives.
Immunogen:: Recombinant fragmemt of human MAP3K8
Clone:: HL2118
Uniprot:: P41279
Synonyms:: augmented in rheumatoid arthritis 2;AURA2;c-COT;Cancer Osaka thyroid oncogene;COT;cot (cancer Osaka thyroid) oncogene;EST;ESTF;Ewing sarcoma transformant;MEKK8;mitogen-activated protein kinase kinase kinase 8;proto-oncogene c-Cot;proto-oncogene serine/threoine protein kinase;Serine/threonine-protein kinase cot;Tpl-2;TPL2;tumor progression locus 2
Extra Details:: This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Shipping Conditions:: Blue Ice