MC1 Receptor antibody [HL1471]

Cannot supply to this region.

SKU:: GTX636945
Additional Names:: melanocortin 1 receptor , CMM5 , MSH-R , SHEP2
Application:: WB, IHC-P, IHC-Fr, IF, ICC
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: PBS, no preservatives.
Immunogen:: Synthetic peptide encompassing a sequence within the Intracellular domain of human MC1 Receptor. The exact sequence is proprietary.
Clone:: HL1471
Uniprot:: Q01726
Synonyms:: alpha melanocyte stimulating hormone receptor;CMM5;MC1-R;Melanocortin receptor 1;melanocyte-stimulating hormone receptor;melanotropin receptor;MSH-R;SHEP2
Extra Details:: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]

Shipping Conditions:: Blue Ice