![TBP antibody [GT453]](https://www.genetex.com/upload/website/prouct_img/normal/GTX634166/GTX634166_42807_20170615_WB_w_23061202_712.webp)
GTX634166
TBP antibody [GT453]
Cannot supply to this region.
- SKU:
- GTX634166
- Additional Names:
- TATA-box binding protein , GTF2D , GTF2D1 , HDL4 , SCA17 , TFIID
- Application:
- WB
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Protein G Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Mouse
- Reactivities:
- Human
- Buffer:
- PBS, no preservatives.
- Immunogen:
- Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human TBP. The exact sequence is proprietary.
- Clone:
- GT453
- Uniprot:
- P20226
- Synonyms:
- GTF2D;GTF2D1;HDL4;SCA17;TATA sequence-binding protein;TATA-binding factor;TATA-box binding protein N-terminal domain;TATA-box factor;TATA-box-binding protein;TFIID;transcription initiation factor TFIID TBP subunit
- Extra Details:
- Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. [provided by RefSeq]
- Shipping Conditions:
- Blue Ice