HSPC142 antibody [GT2810]

Cannot supply to this region.

SKU:: GTX629878
Additional Names:: BRISC and BRCA1 A complex member 1 , C19orf62 , HSPC142 , MERIT40 , NBA1
Application:: WB, IF, ICC
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Protein G Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: PBS, no preservatives.
Immunogen:: Recombinant protein encompassing a sequence within the N-terminus region of human HSPC142. The exact sequence is proprietary.
Clone:: GT2810
Uniprot:: Q9NWV8
Synonyms:: BRCA1-A complex subunit MERIT40;BRISC and BRCA1-A complex member 1;C19orf62;HSPC142;mediator of Rap80 interactions and targeting 40 kDa;mediator of RAP80 interactions and targeting subunit of 40 kDa;MERIT40;NBA1;new component of the BRCA1-A complex;new component of the BRCAA1 A complex
Extra Details:: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.

Shipping Conditions:: Blue Ice