PAPP A antibody [9]

Cannot supply to this region.

SKU:: GTX60974
Additional Names:: pappalysin 1 , ASBABP2 , DIPLA1 , IGFBP-4ase , PAPA , PAPP-A , PAPPA1
Application:: ELISA, WB, IHC-P, IHC-Fr
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Protein A Purified
Storage Conditions:: 2-8[o]C
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: 10mM Phosphate, 500mM NaCl, 15mM Sodium azide.
Immunogen:: Purified human PAPP-A
Clone:: 9
Uniprot:: Q13219
Synonyms:: ASBABP2;aspecific BCL2 ARE-binding protein 2;differentially placenta 1 expressed protein;DIPLA1;IGF-dependent IGFBP-4 protease;IGFBP-4ase;insulin-like growth factor-dependent IGF binding protein-4 protease;Insulin-like growth factor-dependent IGF-binding protein 4 protease;PAPA;PAPP-A;PAPPA1;pappalysin-1;Pregnancy-associated plasma protein A;pregnancy-associated plasma protein A, pappalysin 1
Extra Details:: This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]