Shh antibody [5H4]

Cannot supply to this region.

SKU:: GTX60606
Additional Names:: sonic hedgehog signaling molecule , HHG1 , HLP3 , HPE3 , MCOPCB5 , SMMCI , ShhNC , TPT , TPTPS
Application:: ELISA, Flow Cytometry, WB, IHC-P
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Protein G Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human, Mouse
Buffer:: PBS, 0.05% Sodium azide.
Immunogen:: Purified recombinant fragment of human SHH (AA: 26-161) expressed in E. Coli.
Clone:: 5H4
Uniprot:: Q15465
Synonyms:: HHG-1;HHG1;HLP3;HPE3;MCOPCB5;shh unprocessed N-terminal signaling and C-terminal autoprocessing domains;ShhNC;SMMCI;sonic hedgehog homolog;sonic hedgehog protein;TPT;TPTPS
Extra Details:: This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right

Shipping Conditions:: Blue Ice