Alkaline Phosphatase (Tissue Non-Specific) antibody [2F4]

Cannot supply to this region.

SKU:: GTX60568
Additional Names:: alkaline phosphatase, biomineralization associated , AP-TNAP , APTNAP , HOPS , TNALP , TNAP , TNSALP
Application:: ELISA, Flow Cytometry, WB, IHC-P
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Protein G Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: PBS, 0.05% Sodium azide.
Immunogen:: Purified recombinant fragment of human Alkaline Phosphatase (Tissue Non-Specific) expressed in E. Coli.
Clone:: 2F4
Uniprot:: P05186
Synonyms:: alkaline phosphatase liver/bone/kidney isozyme;alkaline phosphatase, liver/bone/kidney;alkaline phosphatase, tissue-nonspecific isozyme;AP-TNAP;APTNAP;HOPS;HPPA;HPPC;HPPI;HPPO;liver/bone/kidney-type alkaline phosphatase;tissue non-specific alkaline phosphatase;tissue-nonspecific ALP;TNALP;TNAP;TNSALP
Extra Details:: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

Shipping Conditions:: Blue Ice