Cortactin antibody [4C6]

Cannot supply to this region.

SKU:: GTX60419
Additional Names:: cortactin , EMS1
Application:: ELISA, WB, IHC-P
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Unpurified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human, Mouse
Buffer:: Ascites, 0.03% Sodium azide.
Immunogen:: Purified recombinant fragment of human CTTN expressed in E. Coli.
Clone:: 4C6
Uniprot:: Q14247
Synonyms:: 1110020L01Rik;amplaxin;EMS1;ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate);epididymis secretory sperm binding protein;oncogene EMS1;src substrate cortactin
Extra Details:: This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]

Shipping Conditions:: Blue Ice