![AIF antibody [AT22E9]](https://www.genetex.com/upload/website/prouct_img/normal/GTX57664/GTX57664_20200204_IF_w_23061123_754.webp)
![AIF antibody [AT22E9]](https://www.genetex.com/upload/website/prouct_img/normal/GTX57664/GTX57664_20200204_WB1_w_23061123_590.webp)
![AIF antibody [AT22E9]](https://www.genetex.com/upload/website/prouct_img/normal/GTX57664/GTX57664_20200204_WB2_w_23061123_525.webp)
GTX57664
AIF antibody [AT22E9]
Cannot supply to this region.
- SKU:
- GTX57664
- Additional Names:
- apoptosis inducing factor mitochondria associated 1 , AIF , AIFM1 , CMT2D , CMTX4 , COWCK , COXPD6 , DFNX5 , NADMR , NAMSD , PDCD8 , apoptosis inducing factor, mitochondria associated 1
- Application:
- WB, IF, ICC
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Mouse
- Reactivities:
- Human, Mouse
- Buffer:
- PBS, 10% Glycerol, 0.02% Sodium azide.
- Immunogen:
- The clone AT22E9 is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human AIFM3 protein.
- Clone:
- AT22E9
- Uniprot:
- O95831
- Synonyms:
- AIF;apoptosis-inducing factor 1, mitochondrial;apoptosis-inducing factor, mitochondrion-associated, 1;auditory neuropathy, X-linked recessive 1;AUNX1;CMT2D;CMTX4;COWCK;COXPD6;DFNX5;NADMR;NAMSD;PDCD8;programmed cell death 8 (apoptosis-inducing factor);Programmed cell death protein 8;SEMDHL;striatal apoptosis-inducing factor;testicular secretory protein Li 4
- Extra Details:
- This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Aug 2015]
- Shipping Conditions:
- Blue Ice