GTX57230
PXR antibody
Cannot supply to this region.
- SKU:
- GTX57230
- Additional Names:
- nuclear receptor subfamily 1 group I member 2 , BXR , ONR1 , PAR , PAR1 , PAR2 , PARq , PRR , PXR , SAR , SXR
- Application:
- Flow Cytometry, WB, IHC-P
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Porcine, Rat
- Buffer:
- 10mM TBS, 1% BSA, 50% Glycerol, 0.03% Proclin300.
- Immunogen:
- KLH conjugated synthetic peptide derived from human PXR (80-130).
- Uniprot:
- O75469
- Synonyms:
- BXR;nuclear receptor subfamily 1 group I member 2;ONR1;orphan nuclear receptor PAR1;orphan nuclear receptor PXR;PAR;PAR1;PAR2;PARq;pregnane X nuclear receptor variant 2;pregnane X receptor;PRR;PXR;SAR;steroid and xenobiotic receptor;SXR
- Extra Details:
- This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
- Shipping Conditions:
- Blue Ice