TLR4 antibody [76B357.1]

Cannot supply to this region.

SKU:: GTX57153
Additional Names:: toll like receptor 4 , ARMD10 , CD284 , TLR-4 , TOLL
Application:: ChIP, Flow Cytometry, WB, IHC-P, IHC-Fr, IF, ICC, FuncS
Concentration:: 1 mg/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Protein G Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Bovine, Hamster, Human, Mouse, Porcine, Rat
Buffer:: PBS, 0.05% Sodium azide.
Immunogen:: This antibody was developed against a portion of amino acids 100-200 of human TLR4 (NP_612564).
Clone:: 76B357.1
Uniprot:: O00206
Synonyms:: ARMD10;CD284;homolog of Drosophila toll;hToll;TLR-4;TOLL;toll like receptor 4 protein;toll-like receptor 4
Extra Details:: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq]

Shipping Conditions:: Blue Ice