GTX56127
MARCH-I antibody
Cannot supply to this region.
- SKU:
- GTX56127
- Additional Names:
- membrane associated ring-CH-type finger 1 , MARCH-I , RNF171
- Application:
- WB, IHC-P
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- 0.42% Potassium Phosphate, 0.87% NaCl, 30% Glycerol, 0.01% Sodium azide.
- Immunogen:
- KLH-conjugated synthetic peptide encompassing a sequence within the center region of MARCH-I. The exact sequence is proprietary.
- Uniprot:
- Q8TCQ1
- Synonyms:
- E3 ubiquitin-protein ligase MARCH1;E3 ubiquitin-protein ligase MARCHF1;MARCH-I;MARCH1;membrane associated ring finger 1;membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase;membrane-associated RING finger protein 1;membrane-associated RING-CH protein I;RING finger protein 171;RING-type E3 ubiquitin transferase MARCH1;RING-type E3 ubiquitin transferase MARCHF1;RNF171
- Extra Details:
- MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010]
- Shipping Conditions:
- Blue Ice