GTX56106
MED12 antibody
Cannot supply to this region.
- SKU:
- GTX56106
- Additional Names:
- mediator complex subunit 12 , ARC240 , CAGH45 , FGS1 , HOPA , MED12S , OHDOX , OKS , OPA1 , TNRC11 , TRAP230
- Application:
- WB, IHC-P
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 0.42% Potassium Phosphate, 0.87% NaCl, 30% Glycerol, 0.01% Sodium azide.
- Immunogen:
- KLH-conjugated synthetic peptide encompassing a sequence within the center region of MED12. The exact sequence is proprietary.
- Uniprot:
- Q93074
- Synonyms:
- activator-recruited cofactor 240 kDa component;ARC240;CAG repeat protein 45;CAGH45;FGS1;HOPA;human opposite paired;Kohtalo homolog;Kto;MED12S;Mediator complex subunit 12;mediator of RNA polymerase II transcription subunit 12;mediator of RNA polymerase II transcription, subunit 12 homolog;OHDOX;OKS;OPA-containing protein;OPA1;putative mediator subunit 12;thyroid hormone receptor-associated protein complex 230 kDa component;thyroid hormone receptor-associated protein, 230 kDa subunit;TNRC11;TRAP230;trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit);trinucleotide repeat-containing gene 11 protein
- Extra Details:
- The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]
- Shipping Conditions:
- Blue Ice