GTX55731
NR1I3 antibody
Cannot supply to this region.
- SKU:
- GTX55731
- Additional Names:
- nuclear receptor subfamily 1 group I member 3 , CAR , CAR1 , MB67
- Application:
- WB, IF, ICC
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- PBS, 50% Glycerol, 0.05% ProClin 300.
- Immunogen:
- Recombinant fusion protein containing a sequence corresponding to amino acids 103-352 of human NR1I3 (NP_001070948.1).
- Uniprot:
- Q14994
- Synonyms:
- CAR;CAR1;constitutive activator of retinoid response;constitutive active receptor;constitutive active response;constitutive androstane nuclear receptor variant 2;constitutive androstane nuclear receptor variant 3;constitutive androstane nuclear receptor variant 4;constitutive androstane nuclear receptor variant 5;constitutive androstane receptor;MB67;nuclear receptor subfamily 1 group I member 3;orphan nuclear hormone receptor;orphan nuclear receptor MB67
- Extra Details:
- This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Shipping Conditions:
- Blue Ice