GTX55350
CAD (phospho Thr456) antibody
Cannot supply to this region.
- SKU:
- GTX55350
- Additional Names:
- carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase , CDG1Z , EIEE50 , GATD4
- Application:
- IHC-P
- Concentration:
- 1 mg/ml
- Physical State:
- Liquid
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Supplier:
- Genetex
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium azide.
- Immunogen:
- Peptide sequence around phosphorylation site of threonine 456 (P-I-T(p)-P-H) derived from human CAD.
- Uniprot:
- P27708
- Synonyms:
- CAD protein;CAD trifunctional protein;CDG1Z;DEE50;EIEE50;GATD4;multifunctional protein CAD
- Extra Details:
- The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
- Shipping Conditions:
- Blue Ice