WISP1 antibody [7H14]

Cannot supply to this region.

SKU:: GTX53058
Additional Names:: CCN4 , WISP1 , WISP1c , WISP1i , WISP1tc , WNT1 inducible signaling pathway protein 1 , cellular communication network factor 4
Application:: WB
Concentration:: 500 ug/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Protein G Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: PBS, no preservatives.
Immunogen:: Human recombinant WISP-1
Clone:: 7H14
Uniprot:: O95388
Synonyms:: CCN family member 4;WISP1;WISP1 3'UTR-associated RNA 1;WISP1 overlapping transcript 1 (non-protein coding);WISP1-OT1;WISP1-UT1;WISP1c;WISP1i;WISP1tc;Wnt-1-induced secreted protein;WNT1 induced secreted protein 1;WNT1 inducible signaling pathway protein 1
Extra Details:: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]

Shipping Conditions:: Blue Ice