GDNF antibody [12F9]

Cannot supply to this region.

SKU:: GTX52761
Additional Names:: ATF , ATF1 , ATF2 , GDNF , HFB1GDNF , HSCR3 , glial cell derived neurotrophic factor
Application:: WB, FuncS, Neutralisation
Concentration:: 500 ug/ml
Physical State:: Liquid
Species Reactivity:: Human
Purification:: Protein G Purified
Storage Conditions:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Supplier:: Genetex
Host:: Mouse
Reactivities:: Human
Buffer:: PBS, no preservatives.
Immunogen:: Human recombinant GDNF
Clone:: 12F9
Uniprot:: P39905
Synonyms:: astrocyte-derived trophic factor;ATF;ATF1;ATF2;glial cell line-derived neurotrophic factor;HFB1-GDNF;HSCR3
Extra Details:: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]

Shipping Conditions:: Blue Ice